Methioninase Gene Therapy is Synergistic with Recombinant Treatment.

2000 JUL 11 - (NewsRx.com) --

Anticancer results obtained with methioninase gene therapy matched those obtained with recombinant methioninase treatment in a recent study.

"Results obtained over the past 40 years have demonstrated that tumor cells of all types tested have an elevated growth requirement for methioninase compared with normal cells," wrote K. Miki and colleagues, AntiCancer, Inc., California. "Recombinant methioninase (rMETase) cloned from Pseudomonas putida has been found previously to be an effective antitumor agent attributable to deprivation of the extracellular methionine source of the tumor. To degrade intracellular methioninase, we have …